Spray a 9x13-inch pan with nonstick spray.
In a large saucepan, combine the sugar, butter and evaporated milk over medium-high heat.
Stirring constantly with a wooden spoon, heat the mixture until it boils, about 5 minutes.
Turn off the heat and remove the pan from the burner.
Add the chocolate chips, stirring until they melt. Add the marshmallow creme and vanilla and stir until the mixture is well blended.
Pour the mixture into the prepared pan.
Refrigerate until the fudge hardens (at least 4 hours) before cutting.